Research &amp; Innovation

Faculty of Arts & Science

Earth Sciences

Global

Recent satellite data reveal that the Konya Basin in the Central Anatolian Plateau of Türkiye is continually being reshaped over millions of years, according to a new analysis led by Earth scientists at the ��߲ݴ�ý.

The researchers say experimental simulations – combined with geological, geophysical and geodetic data – explain the enigmatic sinking of the basin within the rising plateau interior and further suggests a new class of plate tectonics that has implications for other planets that do not have Earth-like plates such as Mars and Venus.

The study, published in Nature Communications, shows the sinking in the region is due to multi-stage lithospheric dripping – a phenomenon named for the instability of rocky material that makes up Earth’s crust and upper mantle. As dense rock fragments beneath the surface detach and sink into the more fluid layer of the planet’s mantle, major landforms such as basins and mountainous folding of the crust form at the surface.

“Looking at the satellite data, we observed a circular feature at the Konya Basin where the crust is subsiding or the basin is deepening,” says lead author Julia Andersen, a PhD candidate in U of T’s department of Earth sciences in the Faculty of Arts & Science.

“This prompted us to look at other geophysical data beneath the surface where we saw a seismic anomaly in the upper mantle and a thickened crust, telling us there is high-density material there and indicating a likely mantle lithospheric drip.”

Artist’s impression of the multi-stage lithospheric dripping process in Central Anatolia (illustration by Nevena Niagolova)

The results echo a similar investigation by the researchers into the formation of the Arizaro Basin in the Andes Mountains of South America, suggesting the phenomenon can occur anywhere on the planet and explains tectonic processes typically found within mountain plateau regions.

Past studies show the Central Anatolian Plateau has risen by as much as one kilometre over the past 10 million years because of the lithospheric dripping phenomenon.

“As the lithosphere thickened and dripped below the region, it formed a basin at the surface that later sprang up when the weight below broke off and sank into the deeper depths of the mantle,” says Russell Pysklywec, a professor in the department of Earth sciences and a co-author of the study.

“We now see the process is not a one-time tectonic event and that the initial drip seems to have spawned subsequent daughter events elsewhere in the region, resulting in the curious rapid subsidence of the Konya Basin within the continuously rising plateau of Türkiye.”

Andersen adds that the new findings suggest a connection between plateau uplift and basin formation events through the evolution of primary and secondary lithospheric removal. “Essentially, subsidence is occurring alongside the ongoing uplifting of the plateau.”

Andersen and study co-authors, including colleagues at Istanbul Technical University and Çanakkale Onsekiz Mart University in Türkiye, arrived at their findings after recreating the dripping process in laboratory experiments and analyzing their observations.

They built laboratory analogue models to establish how the process may have unfolded based on the data provided by the new measurements, filling a plexiglass tank with polydimethylsiloxane (PDMS) – a silicone polymer fluid approximately 1,000 times thicker than table syrup – to serve as Earth’s fluid lower mantle, adding a mixture of PDMS and modelling clay to replicate the upper-most solid section of the mantle, finishing with a sand-like layer on top made from ceramic and silica spheres to serve as Earth’s crust.

Artist’s impression of two types of lithospheric drip: one produces thickening and uplift of Earth’s crust, while the other results in the formation of a basin at the surface without horizontal deformation (illustration by Julia Andersen/��߲ݴ�ý)

The researchers activated the model by inserting a high-density seed into the PDMS and modelling clay layer to initiate a drip that was subsequently pulled downward by gravity. A set of cameras were positioned above and beside the tank to record any changes over time, capturing a high-resolution image roughly every minute.

“Within 10 hours, we observed an initial phase of dripping, which we call a primary drip. After that primary drip touched the bottom of the box, we saw a second drip had begun to sink to the bottom after 50 hours,” says Andersen. “Both the primary and secondary drip were not causing any horizontal deformation in our artificial crust, which we expect is typically associated with a mantle lithospheric drip.”

The researchers already knew that the primary drip had caused changes in surface topography of the experiment, and wanted to know if the secondary drip would have any effect on the surface since it was a smaller sized drip than the primary drip. “What we noticed was that over time, this secondary drip did pull the crust downward and started to create a basin, despite no horizontal movements in the crust at the surface,” Andersen says. “The findings show these major tectonic events are linked, with one lithospheric drip potentially triggering a host of further activity deep in the planetary interior.”

'Narrative reversal' is key to telling a great story in books, films and TV shows: Study

Christopher.Sorensen — Tue, 17 Sep 2024 14:59:38 +0000

'Narrative reversal' is key to telling a great story in books, films and TV shows: Study

Christopher.Sorensen Tue, 09/17/2024 - 10:59

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(photo by Klaus Vedfelt/Getty Images)

Topic

Rotman School of Management

Subheadline

Researchers found that works featuring changes of fortune, or turning points, were more popular and received better audience reviews

Writers and scholars have long debated what makes for a great story, but Samsun Knight wanted to see whether there was a way to empirically determine which stories will be snore fests and which will leave audiences hungry for more.

Using a scientist’s tools, the novelist and economist found that “narrative reversals,” or peripeteias, were the key factor – lots of them and the bigger the better.

Samsun Knight (supplied image)

Commonly known as changes of fortune or turning points, where characters’ fortunes swing from good to bad and vice versa, Knight and his colleagues found that stories rich in these mechanisms boosted popularity and engagement with audiences through a range of media, from television to crowdfunding pitches.

“The best-written stories were always either ‘building up’ a current reversal, or introducing a new plot point,” says Knight, an assistant professor of marketing at the ��߲ݴ�ý’s Rotman School of Management.

“In our analysis, the best writers were those that were able to maintain both many plot points and strong build-up for each plot point across the course of the narrative.”

The research, co-authored with Matthew D. Rocklage and Yakov Bart of Boston’s Northeastern University, was recently published in the journal Science Advances.

For the study, the researchers analyzed nearly 30,000 television shows, movies, novels, and crowdfunding pitches using computational linguistics, a blend of computer science and language analysis. The approach allowed them to quantify not only the number of a reversals in a text but also their degree or intensity by assigning numerical values to words based on how positive or negative they were.

Movies and television shows with more and bigger reversals were better rated on the popular ratings site IMDb. Books with the most and biggest reversals were downloaded more than twice as often as books with the fewest reversals from the free online library Project Gutenberg. And GoFundMe pitches with more and larger reversals were as much as 39 per cent more likely to hit their fundraising goals.

The Greek philosopher Aristotle was the first to identify peripeteia as a key feature of a good story, with Oedipus Rex serving as a classic example. Other thinkers have since added their ideas, including American playwright and dramaturg Leon Katz, whose scholarship particularly inspired Knight’s research.

“[Katz] described the reversal as the basic unit of narrative – just as a sentence is the basic unit of a paragraph, or the syllogism is the basic unit of a logical proof,” Knight says.

In addition to helping psychologists understand how narrative works to educate, inform and inspire people, the findings may also benefit storytellers of all kinds.

“Hopefully our research can help build a pedagogy for writers that allows them to rely on the accumulated knowledge of Aristotle et al. without having to reinvent the wheel on their own every time,” says Knight.

That includes himself. With another novel on the way, he was recently working on a chapter with a big reveal.

“I realized that this drop might hit harder if I gave the character more positive moments before pulling the rug out from under them.”

Researchers' lab technique could speed forensic analysis in sexual assault cases

Christopher.Sorensen — Tue, 17 Sep 2024 14:43:28 +0000

Researchers' lab technique could speed forensic analysis in sexual assault cases

Christopher.Sorensen Tue, 09/17/2024 - 10:43

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(photo by Science Photo Library/Getty Images)

Chris Sasaki

Topic

Centre for Research and Applications in Fluidic Technologies

Institute of Biomedical Engineering

Donnelly Centre for Cellular & Biomolecular Research

Chemistry

Faculty of Arts & Science

Computer & Electrical Engineering

U of T Mississauga

A team of researchers has developed a new approach to analyzing DNA evidence in sexual assault cases – one that could reduce lengthy delays in the processing of evidence.

While there are almost half a million sexual assaults in Canada every year, many more go unreported because victims are reluctant to come forward.

One of the reasons cited by victims is that analysis of forensic evidence is too slow.

Mohamed Elsayed (supplied image)

“For this research, we read reports and surveys that asked victims why they weren’t reporting assaults,” says the study’s lead author Mohamed Elsayed, who worked on the project as part of his PhD in biomedical engineering at the ��߲ݴ�ý. “And the most common answer was that they didn't have confidence in the justice system – and that lack of confidence was partly because of how long the process takes.”

Elsayed, now a post-doctoral researcher in the department of chemistry in the Faculty of Arts & Science, co-authored the study with, among others, Leticia Bodo, a master’s student in the department of chemistry, and Aaron Wheeler, a professor in the department of chemistry, the Institute of Biomedical Engineering and the Centre for Research and Applications in Fluidic Technologies, a U of T institutional strategic initiative.

All three researchers are also affiliated with the Donnelly Centre for Cellular and Biomolecular Research.

Processing forensic evidence in sexual assault cases is a technical, multi-step process that involves collecting DNA evidence and sending it to a well-equipped forensic laboratory for analysis by a skilled technician. Once there, the sample is first processed to isolate the assailant’s DNA from the victim’s so the assailant’s DNA can then be analyzed and used to identify a suspect.

The entire process can take days, weeks or longer. Most of that time is taken up with transporting the evidence to the lab, where its analysis can be further delayed depending on how many other cases are being investigated.

To speed things up, researchers focused on the first step: separating two individuals’ DNA from a single sample. At present, this is usually done manually by trained and experienced experts.

Elsayed and his collaborators, by contrast, developed a process called ’differential digestion” using digital microfluidics that helped simplify the overall process and reduce the number of manual steps needed to isolate the assailant’s DNA from 13 to five. “Also, because micro-fluidic processes tend to be faster, we expect that one of the eventual benefits will be shortening the overall time needed,” says Elsayed.

What’s more, the new approach could lead to a mobile solution that no longer requires a lab. For example, testing could be done at a hospital, circumventing the lab’s queue.

The new technique, described in a paper published in the journal Advanced Science, is compatible with the technology known as Rapid DNA analysis that is already in use for the second step of identifying an individual from their DNA. The study’s authors, which included researchers from U of T Mississauga’s forensic science program, say the long-term goal is to integrate the two technologies to make the process even more streamlined.

While there remain several challenges to deploying the new technique, Elsayed says he is confident they can be overcome and has turned his efforts toward making it widely accessible and commercially viable.

“Our plan is to develop an instrument that will do in five minutes what currently takes 45,” says Elsayed. “And to run many more samples than previously. Once we do that, the next step would be to introduce the technology to forensic labs and hospitals.

“It will take years, but the potential is very exciting.”

The research was supported by the ANDE Corporation and NSERC Alliance Society.

"I’m grateful to NSERC for having the foresight to establish the ‘Alliance Society’ program which has a mission to ‘address a societal challenge that will result in new natural sciences and engineering knowledge and societal impact,” Wheeler says.

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Forensic Science

U of T engineering students encouraged to consider sustainability when designing future AI systems

Christopher.Sorensen — Mon, 16 Sep 2024 15:10:13 +0000

U of T engineering students encouraged to consider sustainability when designing future AI systems

Christopher.Sorensen Mon, 09/16/2024 - 11:10

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Professors Hans-Arno Jacobsen, left, and Natalie Enright Jerger of the Faculty of Applied Science & Engineering are part of a team that is training computer system designers to integrate sustainability practices into the development of AI and machine learning systems (photo by Jenny Lee)

Matthew Tierney

Topic

Our Community

NSERC

Sustainability

Subheadline

The Sustainable Data Systems for Data Science initiative aims to align Canada’s tech investments with its vision for a carbon-neutral future

The growing global adoption of artificial intelligence technologies, including machine learning, has created a new sustainability challenge: AI systems are energy-intensive – and the more sophisticated they become, the more resources they require.

To help address the issue, a team of experts including the ��߲ݴ�ý’s Hans-Arno Jacobsen and Natalie Enright Jerger – both professors in the Edward S. Rogers Sr. department of electrical and computer engineering at the Faculty of Applied Science & Engineering – are launching an initiative that aims to align Canada’s tech investments with its vision for a sustainable, carbon-neutral future.

The Sustainable Data Systems for Data Science (SDSDS) project aims to train a new generation of computer and data scientists who can combine comprehensive technical skills with sustainability awareness. The project recently received a $1.6-million Collaborative Research and Training Experience (CREATE) grant from the Natural Science and Engineering Research Council of Canada (NSERC).

“A majority of students are unaware of how sustainability informs responsible development of platforms and systems because, frankly, there just aren’t many courses or learning paths available to them in this area,” says Enright Jerger, who holds the Canada Research Chair in Computer Architecture and is director of the division of engineering science.

“Another crucial component of this project is to equip our students with knowledge transfer strategies so they can seed these ideas in the workforce. Today’s trainees becoming tomorrow’s trainers.”

The SDSDS team propose training future computer systems designers to adopt a green approach when developing data analytics platforms and systems. The approach would apply to all aspects of the life cycle of development and deployment – such as hardware infrastructure, software systems and application domains.

To advance knowledge and dialogue on the issue, SDSDS will look to hold cross-university seminars on sustainability challenges and will offer courses on sustainable data science, along with summer school programs focused on energy-efficient software and hardware platforms.

The researchers also aim to connect students with industry via internships and applied research projects, enabling them to gain exposure to current challenges and facilitate cross-pollination of knowledge between industry and academia.

“The awareness about AI’s environmental impact is growing, but there is an expertise gap on how to address this very real problem – not just after the fact, but at inception. SDSDS aims to bridge this gap and prepare for the future resource demands of AI-driven industries,” says Bettina Kemme, professor of computer science at McGill University and team lead at SDSDS, which also includes Semih Salihoğlu of the University of Waterloo, Oana Balmau of McGill University and Essam Mansour of Concordia University.

“The potential of AI and machine learning systems are seemingly limitless,” says Jacobsen, who is the Jeffrey Skoll Chair in Computer Networks and Innovation. “Yet the true genius lies in building machine learning systems founded on sustainability principles. That’s real innovation.”

Researchers develop new method for delivering RNA and drugs into cells

Christopher.Sorensen — Mon, 16 Sep 2024 15:02:15 +0000

Researchers develop new method for delivering RNA and drugs into cells

Christopher.Sorensen Mon, 09/16/2024 - 11:02

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PhD candidate Kai Slaughter, left, and University Professor Molly Shoichet are exploring how ionizable drugs can be used to co-formulate small interfering RNA (siRNA) for more effective intracellular delivery (supplied images)

Qin Dai

Topic

Institute of Biomedical Engineering

Princess Margaret Cancer Centre

Temerty Faculty of Medicine

Donnelly Centre for Cellular & Biomolecular Research

University Health Network

Subheadline

"This could be a game-changer for treating complex conditions where targeting multiple pathways is beneficial, such as cancer and viral infections"

Researchers at the ��߲ݴ�ý and its hospital partners have developed a method for co-delivering therapeutic RNA and potent drugs directly into cells, potentially leading to a more effective treatment of diseases.

The research, published recently in the journal Advanced Materials, explores how ionizable drugs can be used to co-formulate small interfering RNA (siRNA) for more effective intracellular delivery.

The team – including Molly Shoichet, the study’s corresponding author and a University Professor in U of T’s department of chemical engineering and applied chemistry in the Faculty of Applied Science & Engineering – specifically targeted drug-resistant cells with the delivery of a relevant siRNA. The siRNA was discovered study co-author and collaborator David Cescon, a clinician scientist at the Princess Margaret Cancer Centre, University Health Network, and an associate professor in U of T’s Temerity Faculty of Medicine.

“We found that our co-formulation method not only potently delivered siRNA to cells but also simultaneously delivered active ionizable drugs,” said research lead author Kai Slaughter, a PhD candidate in Shoichet’s lab.

“This could be a game-changer for treating complex conditions where targeting multiple pathways is beneficial, such as cancer and viral infections.”

siRNA is a powerful tool in medicine, capable of silencing specific genes responsible for disease, but delivering these molecules into cells without degradation remains a significant challenge. While recent innovations in ionizable lipid design have led to efficiency improvements, traditional nanoparticle formulations are limited in the amount of small molecule drugs they can carry.

When therapeutic formulations are absorbed by cells, small molecule drugs and siRNA are often trapped in small compartments called endosomes, preventing them from reaching their target destination and reducing their effectiveness.

The research team discovered that combining siRNA with ionizable drugs – compounds that change their charge based on pH levels – enhances the stability and delivery efficiency of siRNA inside cells, helping both the siRNA and drug escape the endosome and more effectively reach their destination. This novel method utilizes the protective properties of lipids to safeguard siRNA during its journey through the body and ensure the release of RNA and the drug together within the target cells.

“One of the biggest hurdles in siRNA therapy has been getting these molecules to where they need to go without losing their potency,” Shoichet says.

“Our approach using ionizable drugs as carriers marks a significant step forward in overcoming this barrier, while also showing how drugs and RNA can be delivered together in the same nanoparticle formulation.”

3D-printed soil? U of T startup expands sustainable urban farming footprint in Toronto

Christopher.Sorensen — Wed, 11 Sep 2024 15:07:18 +0000

3D-printed soil? U of T startup expands sustainable urban farming footprint in Toronto

Christopher.Sorensen Wed, 09/11/2024 - 11:07

Cutline

Leo Hua and Adnan Sharif show off fresh basil that was grown with Lyrata’s sustainable farming system at Toronto’s Casa Loma (photo by Liz Intac)

Topic

Entrepreneurship Hatchery

Innovation & Entrepreneurship

Startups

Sustainability

U of T Scarborough

Subheadline

With new installations at Casa Loma and U of T Scarborough, Lyrata is supplying freshly grown produce to local caterers and restaurants

A startup co-founded by a ��߲ݴ�ý graduate student has its roots in an experience that is all too common for many of us.

He kept forgetting to water his plants.

“I was working in a plant immunity biology lab, so if I didn’t water them, I’d have no plants to do experiments with,” says Adnan Sharif, who is pursuing a master’s degree in the department of chemical engineering and applied chemistry in the Faculty of Applied Science & Engineering.

He says his solution was inspired by his father.

“My dad is a mechanical engineering professor at a university in Japan, and he knows a lot about manufacturing materials with porous, three-dimensional structures,” he says. “That’s how I got the idea to make my own 3D-printed soil construct, which could retain water for a week or more.

“That way, I wouldn’t have to go into the lab and water the plants so often.”

The innovation – which Sharif came up as an undergraduate working in the lab of Keiko Yoshioka, a professor in the department of cell and systems biology in U of T’s Faculty of Arts & Science – is one of several that now underpins Lyrata, a startup that grows fresh produce for caterers and high-end restaurants across the Greater Toronto Area.

The company, which got its start in a greenhouse on U of T’s St. George campus, has recently expanded with operations at U of T Scarborough and Casa Loma, a museum, event space and historic site in midtown Toronto.

Growing plants without soil, known as hydroponics, is a technique commonly used in greenhouses worldwide. But Sharif and his team see an opportunity to make the industry more sustainable, starting with the soil replacement that the plants grow in.

“The product that almost everyone uses today is basically the same as house insulation,” Sharif says. “It’s made from rocks that are mined in remote places and shipped hundreds of kilometres to a production facility, where they are heated to thousands of degrees in a giant furnace to make a porous, chemically inert material. This material then needs to be shipped again to where it’s needed, and when you’re finished, you throw it in the garbage.”

By contrast, Lyrata’s SmartSoil is 3D-printed using biopolymers such as polylactic acid, which is derived from corn. These materials can be locally sourced and require much lower temperatures to melt and form into porous structures.

When the growing cycle is complete, the product goes through a low-heat proprietary cleaning process and can be used again. Sharif says that SmartSoil has a total lifespan of about two years, after which it can be composted along with crop residue. Together, these changes greatly lower the carbon footprint of indoor farming.

In 2020, Sharif and his co-founders brought his idea to The Entrepreneurship Hatchery, U of T Engineering’s startup incubator and one of several entrepreneurship hubs across U of T’s three campuses. Through the Hatchery’s Nest process, they were connected with business mentors, including alumnus Xavier Tang, a consultant and venture capitalist who still advises the company today.

Over the next few years, the team evolved, with some original members leaving and others joining. They include Leo Hua, who has been pivotal to speeding the development of 3D printable soil. The concept evolved, too, as the team realized that producing food was a better business for Lyrata than rather than selling their growth medium to other farmers.

The Hatchery team – in particular, Executive Director Joseph Orozco, Go-To-Market Lead Erika J. Murray and a team of work-study students, mentors and legal externs – helped Lyrata develop their technology and business. In 2022, the Hatchery provided $155,000 in seed funding, enabling the founders to be employed by their company and further supporting business development. The funding also enabled the company to rent greenhouse space on campus, where they began growing lettuce to provide to Spaces and Experiences at U of T.

Lyrata also developed something new: a modular unit that works exclusively with their SmartSoil and contains everything required to produce a variety of indoor crops – from lights and growth medium to irrigation systems.

“None of these technological and business developments would have taken place without the generous support of the over 50 Hatchery mentors, work-study students, and legal externs who contributed to our success,” says Sharif.

“Our current concept is what we call farming-as-a-service,” Hua adds. “The SmartGrow unit we developed is small enough to fit into a standard parking spot. Our clients sign a contract with us to place a unit on their site and we take care of everything from planting to harvesting.

“For a flat fee, they get a self-contained farm that provides a reliable quantity of their desired crop over a set period of time.”

In addition to providing a locally sourced, sustainable product, Sharif says the approach can also help mitigate fluctuations in the price of wholesale produce.

“In Canada, most of our lettuce comes from California, which has been dealing with drought and many other issues,” says Sharif. “Supply chain disruptions due to COVID-19 were also a big challenge for restaurants, which have very thin margins to begin with. At one point, the price of lettuce increased by a factor of six, so you can imagine the effect that would have.”

So far, Lyrata has produced more than 15 different types of crops, including basil, parsley and mizuna, also known as Japanese mustard greens.

Support from the U of T Engineering community has been key to Lyrata’s success.

For example, it was a U of T Engineering alumni connection that recently led to Lyrata launching an installation at the historic Casa Loma museum and landmark in Toronto.

“Lyrata’s competitive edge is that they provide an on-site, full service and they do not take up very much space,” says Nikol Watlikiewicz, Casa Loma’s horticulture and grounds manager. “In a small corner of our potting shed, we were able to build two grow units that provide a good yield weekly, without having to train our staff on the complicated system.

“Growing indoors gives us the stability and control that traditional agriculture does not. It’s an excellent example of how engineers can help solve the global food crisis with innovative thinking.”

In August, Lyrata launched another growing unit at U of T Scarborough, located within the Harmony Commons Dining Hall.

The priority for the next few years is growing Lyrata’s crop offerings and client base with ongoing support from The Hatchery. The incubator has facilitated graduate student placements through Mitacs, with matching funds. It also backed a recent $167,500 project with the Ontario and Canadian governments through the Sustainable Canadian Agricultural Partnership program to further advance the yield and efficiency of the SmartSoil system.

“The fact we’ve been able to come this far in such a short time is in large part due to the help we’ve had from U of T Engineering, and especially the Entrepreneurship Hatchery,” says Sharif.

“Whether it was getting seed funding, finding mentors, hiring work-study students or making important connections through their alumni network, we wouldn’t be here without their support.”

Caution needed when drawing links between improving symptoms and unproven remedies: Study

Christopher.Sorensen — Fri, 06 Sep 2024 16:03:17 +0000

Caution needed when drawing links between improving symptoms and unproven remedies: Study

Christopher.Sorensen Fri, 09/06/2024 - 12:03

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(photo by Oleksandra Yagello/Getty Images)

Sunnybrook Staff

Topic

Sunnybrook Health Sciences Centre

Temerty Faculty of Medicine

Institute of Health Policy Management and Evaluation

Dalla Lana School of Public Health

National Taiwan University

Subheadline

"Post-hoc bias can play tricks on patients that can eventually lead to serious disappointments – and for health-care workers, it can ultimately lead to shortfalls in care"

People tend to continue with unproven treatments even if there’s no evidence to suggest an initial marginal improvement in symptoms is anything more than a potential coincidence, a new study has found.

"I've noticed many of my patients take unnecessary vitamins, pills or alternative remedies with little evidence to inform their choice, leading to a lot of distraction, wishful thinking and wasted money,” says senior study author Donald Redelmeier, a staff internist and senior scientist at Sunnybrook Health Sciences Centre, and professor in the department of medicine in the ��߲ݴ�ý’s Temerty Faculty of Medicine.

“Perhaps even more concerning is a false belief that leads to a missed diagnosis that later becomes incurable.”

The study, published in the journal JAMA Network Open, explores “post-hoc bias” – a tendency in reasoning that causes many patients to continue taking dubious or unreliable treatments. The bias encourages a popular misconception: that because one action preceded another later event, the first must have caused the second since it occurred in sequence.

But medical science, the researchers note, stresses that the order of two events does not prove a cause-and-effect since coincidences are frequent. The implication for medical care is that a patient who improved after a treatment is not necessarily a patient who improved because of the treatment.

Instead, other potential explanations include withdrawal from an adverse activity, added rest or the body’s own healing powers.

To test bias across a variety of clinical cases, the researchers ran multiple experiments using hypothetical clinical scenarios administered by a randomized survey of pharmacists and members of the community.

The scenarios described a patient with fatigue or another vague symptom who feels a bit better after trying a vitamin, shampoo, sugar pill or other treatment.

“We found that most respondents suggested continuing the treatment indefinitely even though the change in symptoms might be pure random chance," says Redelmeier, who is also affiliated ICES and the Institute for Health Policy, Management and Evaluation in U of T’s Dalla Lana School of Public Health.

"The post-hoc bias can play tricks on patients that can eventually lead to serious disappointments – and for health-care workers, it can ultimately lead to shortfalls in care."

While attributing an initial improvement in – or lack of – symptoms to a treatment is a quick and intuitive approach, the researchers say the study reinforces the need for both patients and clinicians to be cautious when drawing conclusions.

“An awareness of post-hoc bias will not make it disappear, however we suggest patients and clinicians need to think twice and stay mindful of alternative explanations.”

The study was supported by the Alfred P. Sloan Foundation, a Canada Research Chair in Medical Decision Sciences, Canadian Institutes of Health Research, the PSI Foundation of Ontario and the National Science Foundation.

This story was originally posted at Sunnybrook Research Institute

U of T ranked fourth in the world in research-focused NTU World University Rankings

Christopher.Sorensen — Fri, 06 Sep 2024 15:51:19 +0000

U of T ranked fourth in the world in research-focused NTU World University Rankings

Christopher.Sorensen Fri, 09/06/2024 - 11:51

Cutline

(photo by Matt Volpe)

Topic

Rankings

Subheadline

The National Taiwan University ranking evaluates universities based on research output and impact

The ��߲ݴ�ý climbed one spot to fourth place globally in the latest National Taiwan University ranking, which evaluates universities based on their research output and impact.

U of T’s strong performance in the 2024 edition of the NTU World University Rankings, released this week, puts it in elite global company. The four other schools in the top five were Harvard University, Stanford University, University College London and the University of Oxford.

Among public universities, U of T placed second globally and first in North America.

“This ranking is yet another reminder that the research produced at the ��߲ݴ�ý is truly world-class,” said Leah Cowen, U of T’s vice-president, research and innovation, and strategic initiatives.

“It also reflects our reputation for research excellence and impact across a broad range of fields – from medicine to the social sciences.”

The NTU ranking analyzes scholarly papers and research citations, scoring each institution based on productivity, impact and excellence. The top 1,000 universities were ranked this year with more than 1,500 considered.

In addition to the overall ranking, NTU ranked universities by six broad fields and 27 specific subjects.

U of T ranked among the top 50 institutions worldwide – and first in Canada – in four of the six broad fields. Notably, that includes a rank of second globally in medicine, the same as last year, and third globally in social sciences – up three spots.

U of T also ranked among the top 10 universities globally in five subject categories: clinical medicine (second), neurosciences and behaviour (third), social sciences (third), psychiatry and psychology (fourth) and biology and biochemistry (sixth).

Two other Canadian universities made the top 100 in the main NTU ranking: University of British Columbia (37th) and McGill University (57th).

Overall, U of T continues to be the highest-ranked Canadian university and one of the top-ranked public universities in the five most closely watched international rankings: Times Higher Education’s World University Rankings, QS World University Rankings, ShanghaiRanking Consultancy’s Academic Ranking of World Universities, U.S. News & World Report’s Best Global Universities and National Taiwan University World University Rankings.

Research team explores next-gen vaccines to guard against sexually transmitted infections

Christopher.Sorensen — Wed, 04 Sep 2024 16:07:53 +0000

Research team explores next-gen vaccines to guard against sexually transmitted infections

Christopher.Sorensen Wed, 09/04/2024 - 12:07

Cutline

Aereas Aung, an assistant professor in the Institute of Biomedical Engineering , is developing new tools to study and manipulate immune cells and their reaction to vaccines (photo by Tim Fraser)

Qin Dai

Topic

Institute of Biomedical Engineering

Connaught Fund

Vaccines

Subheadline

"This work could lay the foundation for more effective vaccines that curb the spread of STIs, particularly in marginalized communities disproportionately affected by these diseases”

A research team from the ��߲ݴ�ý is creating a new generation of vaccines that aims to overcome key hurdles faced by some existing formulations.

For example, a common shortcoming of many traditional vaccines is that they can’t produce antibodies in tissues where sexually transmitted infections (STIs) often enter the body.

“Most current vaccines fail to produce sufficient antibodies within mucosal tissues, leaving a significant gap in our defense against sexually transmitted infections,” says Aereas Aung, an assistant professor at the Institute of Biomedical Engineering in the Faculty of Applied Science & Engineering who is leading the research effort.

“Our goal is to develop a novel strategy that leverages the strengths of parenteral vaccination while also targeting the mucosal immune system.”

Normally vaccines are injected parenterally, meaning it is injected into or under the skin, into the muscle or directly into the bloodstream. The vaccine then travels to lymph nodes, which are small glands that help produce antibodies. Mucosal tissues in the cervix and rectum present a unique challenge since the mucus in these areas can break down the vaccine quickly and wash it away, making it difficult to reach the lymph nodes and be effective.

Aung’s research proposes fusing a protein carrier to the disease antigens, allowing it to reach distant mucosal lymph nodes after injection.

“We aim to incorporate potent immunostimulatory components into our antigen construct, optimizing its distribution and enhancing mucosal antibody responses,” says Aung.

“If successful, this work could lay the foundation for more effective vaccines that curb the spread of STIs, particularly in marginalized communities disproportionately affected by these diseases.”

Aung’s project is one of 51 U of T faculty members whose work is being supported by the Connaught New Researcher Awards in the most recent round – and one of eight at U of T Engineering. The award helps early-career faculty members establish their research programs.

The other U of T Engineering researchers whose projects are supported by the award are: 

Mohammed Basheer, department of civil and mineral engineering – Integrated hydrological-statistical method and tool for landslide susceptibility mapping in a changing climate
Daniel Franklin, Institute of Biomedical Engineering – Development of equitable pulse oximeters
Sarah Haines, department of civil and mineral engineering – Open Plenums & Indoor Environments (OPEN): Evaluating the impact of return air systems on indoor environmental quality
Mark Jeffrey, Edward S. Rogers Sr. department of electrical and computer engineering – Productively surmounting the memory wall with task parallelism
Caitlin Maikawa, Institute of Biomedical Engineering – Affinity-directed dynamic polymer materials for biomarker sensing
Mohamad Moosavi, department of chemical engineering and applied chemistry – Learning the Language of Metal-Organic Frameworks Topology
Cindy Rottmann, Institute for Studies in Transdisciplinary Engineering Education and Practice (ISTEP) – But I could be fired! How early career engineers hold the public paramount from organizationally subordinate locations

Virtual and augmented reality can temporarily change the way people perceive distances: Study

Christopher.Sorensen — Fri, 30 Aug 2024 17:23:24 +0000

Virtual and augmented reality can temporarily change the way people perceive distances: Study

Christopher.Sorensen Fri, 08/30/2024 - 13:23

Cutline

U of T researchers found that people moved differently in virtual reality and augmented reality, and that these changes led to temporary movement errors in the real world (photo by D-BASE/Getty Images)

Jelena Damjanovic

Topic

Faculty of Kinesiology & Physical Education