Leslie Dan Faculty of Pharmacy

PhD student's radiopharmaceutical to play key role in clinical trial for lung cancer treatment

rahul.kalvapalle — Tue, 26 Nov 2024 20:59:25 +0000

PhD student's radiopharmaceutical to play key role in clinical trial for lung cancer treatment

rahul.kalvapalle Tue, 11/26/2024 - 15:59

Cutline

Stephanie Borlase developed a radiopharmaceutical, which will be used during a clinical trial at Sunnybrook Health Sciences Centre, to track delivery of immunotherapy drugs across the blood-brain barrier (photo by Dana Thompson)

Eileen Hoftyzer

Topic

Breaking Research

Sunnybrook Health Sciences Centre

Graduate Students

Leslie Dan Faculty of Pharmacy

Subheadline

The compound developed by U of T's Stephanie Borlase will be used to track delivery of immunotherapy drugs to metastases in the brain

A radiopharmaceutical developed by ��߲ݴ�ý PhD student Stephanie Borlase is poised to play a key role in a clinical trial that could inform improvements to lung cancer treatment.

The trial at Sunnybrook Health Sciences Centre, planned for 2025, will test whether ultrasound can disrupt the blood-brain barrier and increase uptake of immunotherapy into brain metastases – tumours caused by cancer cells spreading to the brain from elsewhere in the body.

Although immunotherapy has shown potential as a treatment for lung cancer, it is not able to cross the blood-brain barrier. Borlase’s radiopharmaceutical, which she developed as part of her doctoral research at the Leslie Dan Faculty of Pharmacy, will be used to track delivery of immunotherapy drugs to brain metastases with a PET (positron emission tomography) scan.

“This project provides me with the opportunity to learn different aspects of research and be on the forefront of patient treatments,” says Borlase. “It is such an amazing opportunity to be able to see what is happening in the hospital with current patients and clinical trials and know that my research is actually getting to patients.”

Borlase completed her undergraduate and master’s degrees at the University of Manitoba, before seeking out a PhD program where she could conduct research that could potentially be translated into therapies for patients with hard-to-treat cancers.

In 2022, she began her PhD with Professor Raymond Reilly, director of the Centre for Pharmaceutical Oncology (CPO), whose research focuses on developing radiopharmaceuticals to image and treat cancer.

By attaching radioactive isotopes to highly targeted agents, radiopharmaceuticals allow clinicians to image tumours through scans and deliver therapeutic doses of radiation directly to the tumour.

Borlase has been working towards pairing the immunotherapy drug pembrolizumab (also known by the brand name Keytruda) with a radioactive isotope that can be imaged by PET – resulting in a radiopharmaceutical that could allow physicians to determine whether the therapy enters the brain and concentrates better in tumours after the application of focused ultrasound.

For the first two years of her PhD, Borlase worked in the CPO’s Good Manufacturing Practices facility to prepare the new radiopharmaceutical for clinical trials, optimizing and formulating the drug in a quality suitable for use in humans, and testing it in pre-clinical models.

Reilly says that this is an exceptional experience for a graduate student. “One of the greatest impacts and rewards of pharmaceutical sciences research is to see your work advanced to a clinical trial to make a difference in patient outcomes, which Stephanie has this wonderful opportunity to do,” he says.

“Not only is she developing the radiopharmaceutical, but she will be working closely with the oncologists and imaging specialists to design and conduct the trial and will get first-hand experience in seeing the results of her PhD research in the PET images of the patients in the trial.”

The trial follows on the heels of another study in which clinicians and scientists at Sunnybrook used a radiopharmaceutical provided by Reilly’s team to track the delivery of a breast cancer drug to brain metastases, resulting in the first evidence that the technique improved uptake of the drug.

For her part, Borlase says she hopes the trial will lead to better therapies for a form of cancer that is notoriously difficult to treat.

“I always hope that researchers can develop new treatments for cancer because it is such a terrible disease that is never going to disappear. Even if we cannot completely cure the brain metastases, we can work to prolong survival to give these individuals more time with their families and friends,” says Borlase, who recently received a Research Training Award from the Canadian Cancer Society and Brain Canada Foundation.

“It's such a rare opportunity for PhD students to be able to work with clinician-scientists or oncologists and actually see their research translate into a clinical setting, so the fact that I am able to do this is incredible.”

Why it's important to get your 2024 flu shot – and how to get it

Christopher.Sorensen — Thu, 07 Nov 2024 14:23:42 +0000

Why it's important to get your 2024 flu shot – and how to get it

Christopher.Sorensen Thu, 11/07/2024 - 09:23

Cutline

The flu vaccine is especially important for adults aged 65 years or older, pregnant people and individuals who have medical conditions that put them at higher risk of complications from influenza infection, U of T experts say (photo by Canva)

Ishani Nath

Topic

Our Community

Centre for Vaccine Preventable Diseases

Dalla Lana School of Public Health

Leslie Dan Faculty of Pharmacy

Subheadline

U of T experts on the flu vaccine, where it's available and when's the best time to get it

None of Jeff Kwong’s patients has asked him about the influenza vaccine yet this fall – but the family physician wants to make sure that getting vaccinated is on people’s radar.

That’s because influenza causes an estimated 12,200 hospitalizations and 3,500 deaths in Canada each year.

Moreover, public health officials are doubly concerned this season because of a strain of influenza circulating in wild birds and some agricultural animals. While the risk of avian influenza to the general population remains low, A H5N1 has nevertheless infected some humans who have close contact with sick animals.

“While current influenza vaccines don’t protect against avian influenza, they may reduce the risk of infection with human influenza viruses and therefore the possibility of both human and avian influenza viruses infecting someone at the same time,” says Kwong, an associate scientist at Sunnybrook Research Institute and professor at the ��߲ݴ�ý’s Dalla Lana School of Public Health.

“These co-infections could create a new ‘version’ of influenza that might spread easily among humans and cause very severe disease.”

What is influenza?

Influenza is a respiratory disease that typically causes fever, cough and body aches. While many people recover from influenza within a week to 10 days, for some, an infection can cause severe illness.

“It’s a good idea for everyone aged six months or older to get an influenza vaccine, but it’s especially important for adults aged 65 years or older, pregnant people and individuals who have medical conditions that put them at higher risk of complications from influenza infection,” says Kwong, who is the associate director of U of T’s Centre for Vaccine Preventable Diseases (CVPD), adding that medical conditions of concern include heart diseases, diabetes and even obesity.

The most common reason Canadians give for not getting a flu shot is because they don’t think it’s necessary – a sentiment Natalie Crown, associate professor, teaching stream, in the Leslie Dan Faculty of Pharmacy, has heard before.

“Sometimes people will tell me they don’t get vaccinated because they think they don’t need it – for example, they’ll say they are healthy and rarely get sick themselves,” says Crown, who is also a CVPD member. “The reality is getting the flu vaccine is one of most effective ways of protecting ourselves from the flu and its complications, and we are doing our part to protect the more vulnerable people around us who are at higher risk of developing complications from the flu.”

U of T’s Discovery Pharmacy's new location in the atrium of the Leslie Dan Faculty of Pharmacy building is among the places U of T community members can get their shot across the three campuses (photo by Dana Thompson)

When to get the influenza vaccine

The flu season doesn’t have a precise start and end date. According to the National Advisory Committee on Immunizations (NACI), influenza season typically starts in December but can start as early as October or as late as February.

Influenza vaccines were first made available for high-risk individuals and then for the public, beginning in late October and early November.

Since antibodies generated by influenza vaccines gradually decrease over time, Kwong takes a strategic approach to timing his influenza vaccine – but notes that may not be the best approach for everyone.

“I tend to wait until around mid-November to get my influenza vaccine, so I will be protected in December when influenza activity often starts, and I can be fairly confident that the vaccine will still offer some protection up to May,” says Kwong. “However, for those at high risk, getting the influenza vaccine in late October is not a bad idea because occasionally influenza activity can start earlier than December.”

Where to get the influenza vaccine

Influenza vaccines are typically available at local community pharmacies, through primary care providers or at dedicated community clinics offered by public health units across the country.

Members of the U of T community can also visit ��߲ݴ�ý for more information on where to get influenza, as well as COVID-19, vaccines across the university’s three campuses.

Learn more about vaccines at ��߲ݴ�ý

U of T receives $25-million gift from Myron and Berna Garron for Scarborough Academy of Medicine and Integrated Health

Christopher.Sorensen — Mon, 23 Sep 2024 13:58:19 +0000

U of T receives $25-million gift from Myron and Berna Garron for Scarborough Academy of Medicine and Integrated Health

Christopher.Sorensen Mon, 09/23/2024 - 09:58

Cutline

(Image supplied)

Advancement Staff

Topic

Our Community

David Palmer

Lawrence Bloomberg Faculty of Nursing

Scarborough Academy of Medicine and Integrated Health

Temerty Faculty of Medicine

Leslie Dan Faculty of Pharmacy

Meric Gertler

U of T Scarborough

Subheadline

The donation supports the much-needed training of health professionals in the underserved Scarborough and Eastern GTA region

A $25-million gift from Myron and Berna Garron will contribute significantly to the construction of a new state-of-the-art facility at ��߲ݴ�ý Scarborough that will house the Scarborough Academy of Medicine and Integrated Health (SAMIH). The gift will also support programming and faculty development – in collaboration with hospital partners such as Scarborough Health Network and Michael Garron Hospital – helping to ensure that SAMIH learners have access to a world-class education right in Scarborough and the Eastern GTA.

The ��߲ݴ�ý will name the new building the Myron and Berna Garron Health Sciences Complex, in honour of the Garrons’ exceptional generosity.

“Myron and Berna Garron’s extraordinary benefaction will help us to realize our vision for the Scarborough Academy of Medicine and Integrated Health – to educate health-care professionals from the region, in the region and for the region,” said Meric Gertler, president of U of T. “On behalf of the ��߲ݴ�ý, I thank them for their leadership in the advancement of this crucial mission.”

Helping to revitalize the health-care landscape

SAMIH, the first hub for educating health professionals in Scarborough and the Eastern GTA and the only medical school in the region, was established to address the critical shortage of family physicians and specialists in the fast-growing area by training health providers who reflect the community. The training will take place in partnership with local hospitals, primary care centres and community agencies.

Once the program is fully up and running, SAMIH will have 160 medical students and a combined total of 252 physician assistants, physical therapists and nurse practitioners enrolled. Three top-ranked U of T faculties – the Temerty Faculty of Medicine, the Lawrence Bloomberg Faculty of Nursing and the Leslie Dan Faculty of Pharmacy – will expand educational programming to this hub. These students will be based at the new Myron and Berna Garron Health Sciences Complex, which will also serve as a base for U of T Scarborough undergraduates studying health sciences.

The Myron and Berna Garron Health Sciences Complex, currently under construction, will feature an anatomy lab for medical students, two large classrooms equipped with state-of-the-art technology, a 25-bed clinical skills lab and 10 instructional labs. To provide hands-on learning and serve the community directly, the facility will house three teaching clinics offering public services: a clinical psychology clinic, a nurse practitioner clinic and a satellite of U of T’s Discovery Pharmacy.

SAMIH medical trainees will undertake clinical rotations at several area hospitals, including Scarborough Health Network, Lakeridge Health, Ontario Shores Centre for Mental Health Sciences and Michael Garron Hospital – named in memory of Myron and Berna Garron’s late son, who was born there and later died of cancer at the age of 13. The Garrons’ $50-million donation in 2015 to what was then Toronto East General Hospital has resulted in remarkable benefits for people in the region.

"We envision SAMIH as closing the circle on providing for total patient care, from educating professionals to delivering care bedside,” said Myron and Berna Garron. “In an era of extensive shortages of vital health practitioners, we are proud to help fill this educational and training gap, especially for the underserved area of Scarborough and the Eastern GTA."

SAMIH is expected to provide numerous benefits for the area. By increasing the number of health providers who will have received U of T’s top-tier education, SAMIH will help improve access and care for patients who live in the region, extend the availability of various health-care services via its public clinics, provide opportunities for local students from diverse backgrounds to consider becoming a health professional and increase the likelihood of health professionals trained in Scarborough to practice locally.

Furthermore, the partnerships with Scarborough Health Network and Michael Garron Hospital will strengthen research and teaching links between the university and the hospitals.

“This generous investment from Myron and Berna Garron is a commitment to the future of health care; through their support of SAMIH and their partnership with Michael Garron Hospital, they’re enabling knowledge creation and sharing that will benefit our communities locally and more broadly,” said Melanie Kohn, president and CEO of Michael Garron Hospital. “The Garrons’ gift to our hospital will establish our first chair in education, in partnership with the ��߲ݴ�ý, which will advance our ability to train tomorrow’s outstanding health-care leaders.”

A community of support

SAMIH was made possible by the Government of Ontario’s commitment to fund the expansion of medical education as part of its strategy to address the critical shortage of health professionals in the province.

“On behalf of Premier Doug Ford and our government, I want to thank Myron and Berna Garron for their generous donation to the Scarborough Academy of Medicine and Integrated Health,” said Sylvia Jones, Ontario’s deputy premier and minister of health. “Your support builds on the largest expansion of medical education that our government has undertaken in 15 years, training more doctors in the GTA than ever before to ensure people can access care in their communities for years to come.”

In a further boost for funding the building’s construction, Myron and Berna Garron’s donation triggers $10 million in matching funds from a $25-million gift to SAMIH from Orlando Corporation in 2022.

The five-storey, purpose-built Myron and Berna Garron Health Sciences Complex is located at U of T Scarborough at the intersection of Military Trail and Morningside Avenue, across from the Toronto Pan Am Centre, and is expected to open in the fall of 2026.

“This gift speaks to Myron and Berna Garron’s appreciation of how health-care education enables healthy lives – a key priority of Defy Gravity: The Campaign for the ��߲ݴ�ý,” said David Palmer, vice-president of advancement at U of T. “We are deeply grateful for this generous donation and the impact it will have on the health of those in Scarborough and the Eastern GTA. The Garron family’s generosity exemplifies how philanthropy can help address inequities and help shape the future of health care in our communities.”

U of T leaders react

“As home to the Scarborough Academy of Medicine and Integrated Health, the ��߲ݴ�ý Scarborough is delighted for this opportunity to increase our impact on the community. SAMIH will attract a diverse pool of local talent and afford graduates the ability to establish their careers in Scarborough and the Eastern GTA – an asset for students with personal ties to the region and for a population in great need of more accessible health care.”

—Linda Johnston, U of T vice-president and principal of U of T Scarborough

“Building a new health sciences complex to house this region’s first medical academy is a historic undertaking. Creating an academy that is advancing health equity as a key priority is even more exceptional. This is a unique opportunity for Temerty Faculty of Medicine to expand the reach of our world-class programs, innovate teaching models and play a critical role in a pipeline that will infuse the health-care system with a steady stream of much-needed physicians and other health-care professionals.”

—Lisa Robinson, dean, Temerty Faculty of Medicine and vice-provost, relations with health-care institutions

“Thanks to the Garrons’ substantial support of the new Myron and Berna Garron Health Sciences Complex, students from the Lawrence Bloomberg Faculty of Nursing will have the opportunity to advance their nursing expertise in a clinic that is embedded within the community. This unique interprofessional environment will ensure graduates of our nurse practitioner program are well-equipped to meet the urgent need for primary health care in the region.”

—Robyn Stremler, dean, Lawrence Bloomberg Faculty of Nursing

“We’re thrilled that U of T pharmacy students will train on rotation at the Discovery Pharmacy within the new Myron and Berna Garron Health Sciences Complex. This additional location offering clinical training in an interdisciplinary setting will be a boon to the profession, given how the scope of practice for pharmacists continues to expand and evolve to better support the people and communities we serve.”

—Lisa Dolovich, dean, Leslie Dan Faculty of Pharmacy

U of T community members recognized with Order of Canada

bresgead — Thu, 04 Jul 2024 16:49:13 +0000

U of T community members recognized with Order of Canada

bresgead Thu, 07/04/2024 - 12:49

Cutline

(photo by Sgt Johanie Maheu, Rideau Hall, OSGG-BSGG)

Adina Bresge

Topic

Our Community

Temerty Faculty of Medicine

Unity Health

Institute of Health Policy Management and Evaluation

Alumni

Chemistry

Dalla Lana School of Public Health

Faculty of Applied Science & Engineering

Faculty of Arts & Science

Faculty of Music

Hospital for Sick Children

Leslie Dan Faculty of Pharmacy

Order of Canada

Political Science

St. Michael's College

University College

University Health Network

Victoria College

Subheadline

"The Order of Canada recognizes individuals who have made positive and lasting impacts on communities here in Canada or who have brought honour to our country abroad"

An innovator in chemical catalyst development. A global leader in cardiac surgery and care. And a public health expert who led the rollout of Canada’s first colon cancer screening program.

These are a few members of the ��߲ݴ�ý community who were recently honoured with appointments or promotions within the Order of Canada.

The Governor General recently announced 83 new appointments to the Order of Canada, including two promotions within the Order.

They include Doug Stephan, a University Professor of chemistry in the Faculty of Arts & Science; Lee Errett, a professor in the Temerty Faculty of Medicine’s department of surgery, and Linda Rabeneck, a health executive and professor in the Temerty Faculty of Medicine and the Dalla Lana School of Public Health.

Established in 1967, the Order of Canada is one of the country’s highest honours, recognizing extraordinary contributions across all sectors of society.

“The Order of Canada recognizes individuals who have made positive and lasting impacts on communities here in Canada or who have brought honour to our country abroad,” Gov. Gen. Mary Simon said in a statement.

Here is a list of U of T faculty, alumni and supporters who were appointed to, or promoted within, the Order of Canada in the latest round of honourees.

Current and former faculty

Edward Cole, a staff nephrologist at Toronto General Hospital and professor in the Temerty Faculty of Medicine’s department of medicine, was named a Member of the Order for his dedication to advancing and delivering care to people living with kidney disease, his instrumental role in establishing a globally impactful kidney-paired donation program and his leadership as former physician-in-chief at the University Health Network.

Lee Errett, a professor in the Temerty Faculty of Medicine’s department of surgery, was appointed a Member of the Order for his transformative leadership in cardiac research and care, including his role in establishing St. Michael’s Hospital as a world-class centre for cardiac surgery, his dedication to educating future medical leaders and providing care in underserved areas worldwide.

Franklyn Griffiths, a professor emeritus and George Ignatieff Chair Emeritus of Peace and Conflict Studies in the department of political science in the Faculty of Arts & Science, was appointed a Member of the Order for his scholarship on Russian affairs which has advanced the Western world’s understanding of Soviet politics. An expert in Arctic international relations, Griffiths helped create the Arctic Council and pushed for Indigenous voices to play a central role in the council’s workings.

Beverley Johnston, an internationally renowned percussionist who is an adjunct professor in the Faculty of Music, was appointed an Officer of the Order for her work developing and promoting Canadian music to audiences around the world. Working in a male-dominated field, Johnston’s unconventional performances combine classical transcriptions, contemporary music and an element of theatre.

Daphne Maurer, a professor emeritus of psychology, neuroscience and behaviour at McMaster University who holds a status appointment at U of T’s Institute of Health Policy Management and Evaluation in the Dalla Lana School of Public Health, was appointed an Officer of the Order for her research on visual and cognitive development in early childhood.

Linda Rabeneck, a gastroenterologist, health executive and professor in the Temerty Faculty of Medicine and the Dalla Lana School of Public Health, was named a Member of the Order for her leadership in colorectal cancer screening and prevention. Formerly the director of the Division of Gastroenterology at U of T, she led the rollout of ColonCancerCheck, Canada’s first province-wide screening program.

Stephen Randall, who earned his master's degree and doctorate at U of T and taught at the university from 1971 to 1974, was named a Member of the Order for his academic contributions and advisory role in international relations. A professor emeritus at the University of Calgary, Randall’s expertise in myriad issues affecting the United States and Latin America, notably Colombia, has informed Canada’s foreign policy.

Bibudhendra Sarkar, senior scientist emeritus at the Research Institute of the Hospital for Sick Children and professor emeritus at U of T’s department of biochemistry in the Temerty Faculty of Medicine, was named a Member of the Order for his achievements in advancing medical research in Canada and abroad. He discovered a novel treatment for patients with Menkes disease, a rare genetic condition, and led international efforts in South and Southeast Asia to address public health crises from contaminated groundwater.

Jonathan Scott Rose, a professor in the Edward S. Rogers Sr. department of electrical and computer engineering in the Faculty of Applied Science & Engineering, was named a Member of the Order for his pioneering work in architecture and software used in field-programmable gate arrays. Rose served as the chair of the department from 2004 to 2009 and received his PhD degree in electrical engineering from U of T in 1986.

Doug Stephan, a University Professor in the department of chemistry in the Faculty of Arts & Science, was named an Officer of the Order in recognition his world-leading research in inorganic and organometallic chemistry. His many achievements include discovering – and commercializing – a new class of catalysts that is now used in one of the largest chemical manufacturing facilities in the world. He also achieved global renown for founding the field of “Frustrated Lewis Pair” chemistry.

Alumni and friends

Sleight-of-hand artist David Ben, who graduated from University College in 1983, was named a Member of the Order for his four decades of dedication to the exploration, development and preservation of magic, including penning several books on the subject and co-founding the Magicana organization.

William Fox, a research fellow and adjunct professor at Trent University who earned his honours bachelor of arts and master of arts in archeology at U of T, was named a Member of the Order for his distinguished contributions to Canadian archeology, his leadership in the Ontario Archaeological Society, and his steadfast advocacy for the involvement of Indigenous communities in preserving their material heritage.

Martha Friendly, who founded the Childcare Resource and Research Unit at U of T’s Centre for Urban and Community Studies in the early 1980s, was appointed an Officer of the Order for her work with the now-independent non-profit and her advocacy for accessible, publicly funded early childhood education and care, and women’s equality.

Rosemary Ganley, a writer, activist, teacher and an alumna of St. Michael’s College, was named a Member of the Order for her lifelong advocacy for human rights, gender equity, and social justice, including co-founding Jamaican Self Help, an organization of Canadians working to support the development of healthy Jamaican communities.

Arnie Gelbart, a member of the Chancellors’ Circle of Benefactors, was named a Member of the Order for his decades-long leadership in independent film and television in his role as founder, executive producer and CEO of Galafilm Productions Inc.

Judy Kent was named a Member of the Order for championing sport as a catalyst for social change, her advocacy for gender equality and inclusion and her leadership in international support. Among her achievements: She was the first woman to serve as both president of Commonwealth Sport Canada and Canada’s chef de mission for the Commonwealth Games, and her paper on sport for international development laid the foundation for the SportWORKS program.

James David Meekison, with a 45-year career spanning investment banking, cable television and private equity, was named a Member of the Order for his extensive philanthropy. The Jim Meekison and Carolyn Keystone Foundation supported U of T’s Leslie Dan Faculty of Pharmacy’s efforts to launch the Discovery Pharmacy on the St. George campus.

Michael Perley, a U of T alumnus who completed a master’s degree in French language and literature, was named a Member of the Order for his lifelong dedication to tackling environmental and health challenges. He has been an advocate for tighter tobacco control laws, reducing second-hand smoke exposure and has led coalitions on acid rain and air pollution.

Dan Poenaru, a pediatric surgeon and professor at McGill University who earned two degrees at U of T, was named a Member of the Order for his contributions to pediatric surgery in Africa, including establishing a surgical unit and training program in Kenya, co-founding three medical schools and leading initiatives for children's surgery globally.

Vaira Vike-Freiberga, an alumna of Victoria College and the first woman to serve as Latvia’s president, was named an honorary Officer of the Order for her work enriching Canada-Latvia relations and for reflecting Canadian values abroad.

– with files from Mariam Matti and Rahul Kalvapalle

‘Give yourself grace’: Pharmacy grad from Nigeria reflects on U of T journey

rahul.kalvapalle — Thu, 13 Jun 2024 13:46:18 +0000

‘Give yourself grace’: Pharmacy grad from Nigeria reflects on U of T journey

rahul.kalvapalle Thu, 06/13/2024 - 09:46

Cutline

Theodora Udounwa completed her U of T undergraduate degree in just two years before studying to be a pharmacist at the Leslie Dan Faculty of Pharmacy (photo by Steve Southon)

Eileen Hoftyzer

Topic

Our Community

Convocation 2024

Leslie Dan Faculty of Pharmacy

St. Michael's College

Subheadline

At age 21, Theodora Udounwa is graduating with a Doctor of Pharmacy degree

Theodora Udounwa was 15 years old when she left her family in Nigeria and traveled to Canada to begin a bachelor of science at the ��߲ݴ�ý.

Born and raised in Abuja, Udounwa graduated from high school at an unusually young age due to a combination of an early start to kindergarten and skipping a grade due to outstanding academic performance.

It was a trend that would continue at U of T. After only two years as an undergraduate, specializing in pharmacology and biomedical toxicology with a minor in physiology, Udounwa began her doctor of pharmacy (PharmD) program at the Leslie Dan Faculty of Pharmacy.

“Pharmacy was always the plan. I enjoyed pharmacology greatly, but I was also interested in patient care, and I saw pharmacy as a bridge between applying those theoretical principles to patient care,” says Udounwa, who graduated with her PharmD last week at only 21 years old. “There are also a lot of career options in addition to patient care, like academic and research, that I thought would be a good fit for me.”

Like many youths in Nigeria, Udouwna attended boarding school during middle school and high school – an experience that stood her in good stead when she moved into St. Michael’s College residence, where she was younger than her peers. The proximity to her older sister – who attended university in nearby Hamilton – and an aunt in Ajax meant she was able to spend holidays with family members in the area.

Udouwna also took it upon herself to get involved with student groups such as the Nigerian Students’ Association, where she was able to meet students from her home country and share her culture.

Starting the PharmD program during the first year of the COVID-19 pandemic, Udounwa grasped the opportunity to contribute to the public health response and strengthen her training, delivering more than 1,600 COVID-19 vaccinations as well as numerous flu shots at Discovery Pharmacy pop-up clinics.

She also completed rotations at Shoppers Drug Mart, the Hospital for Sick Children, Toronto General Hospital, St. Michael’s Hospital (Unity Health Toronto), the outpatient pharmacy at the Centre for Addiction and Mental Health (CAMH) and the Canadian Armed Forces.

All along, she stayed involved with student groups, holding several positions with the Black Pharmacy Students’ Association and the U of T chapter of the Canadian Association of Pharmacy Students and Interns (CAPSI).

She says one of the highlights of her time at U of T was attending CAPSI’s 2023 professional development week in Saskatoon, where she supported 16 U of T delegates and took advantage of several educational and networking opportunities. “It was great to connect with students from other pharmacy schools, and I appreciated the opportunity to expand my professional skills and clinical knowledge,” she says. “We also had the chance to visit an Indigenous heritage site, Wanuskewin, and learn about Indigenous history and culture, which was very enriching.”

Udounwa’s involvement in extracurricular activities earned her numerous accolades including a U of T Student Leadership Award and a Canadian Pharmacists’ Association Centennial Leadership Award. “Devoting time to volunteering and participating in student groups has enabled me to facilitate macro-level changes that directly impact the pharmacy student community. It has also fostered my personal and professional growth through forming connections with and learning from students and practice leaders," Udounwa said upon receiving her Student Leadership Award earlier this year.

Looking ahead, Udounwa says she’s keeping her options open but envisions working directly with patients in some capacity. Her next step: an industry residency at pharma giant Novo Nordisk's medical affairs and strategic operations department.

Having navigated the challenges of moving to a new country for university and experiencing a new culture, Udounwa says she would advise incoming university students to be kind to themselves as they forge their journey.

“This is a pivotal moment in our careers; be patient and give yourself grace as you go through the process and navigate through that uncertainty to the next great opportunity.”

U of T researchers' approach to producing neural cells could yield new treatments for Parkinson’s

rahul.kalvapalle — Mon, 13 May 2024 13:03:19 +0000

U of T researchers' approach to producing neural cells could yield new treatments for Parkinson’s

rahul.kalvapalle Mon, 05/13/2024 - 09:03

Cutline

PhD Student Andy Yang, left, and Professor Stephane Angers, right, at the Donnelly Centre for Cellular and Molecular Biology are advancing a novel approach to developing dopaminergic neurons (supplied images)

Anika Hazra

Topic

Breaking Research

Institutional Strategic Initiatives

Temerty Faculty of Medicine

Donnelly Centre for Cellular & Biomolecular Research

Graduate Students

Leslie Dan Faculty of Pharmacy

Medicine by Design

Parkinson's

Research & Innovation

Subheadline

An antibody was used to selectively activate a receptor in a molecular signalling pathway to develop dopaminergic neurons

Researchers at the ��߲ݴ�ý believe they’ve found a way to better control the generation of key neurons depleted in Parkinson’s disease – suggesting a potentially new approach to addressing a disease with no cure and few effective treatments.

In preclinical studies, the researchers used an antibody to selectively activate a receptor in a molecular signalling pathway to develop dopaminergic neurons. These neurons produce dopamine, a neurotransmitter critical to brain health.

While researchers around the world have been working to coax stem cells to differentiate into dopaminergic neurons to replace those lost in patients living with Parkinson’s disease, the efforts have so far been hindered in part by an inability to target specific receptors and areas of the brain.

“We used synthetic antibodies that we had previously developed to target the Wnt signaling pathway,” said principal investigator Stephane Angers, who is director of U of T’s Donnelly Centre for Cellular and Molecular Biology and a professor in the Leslie Dan Faculty of Pharmacy and the Temerty Faculty of Medicine.

“We can selectively activate this pathway to direct stem cells in the midbrain to develop into neurons by targeting specific receptors in the pathway. This activation method has not been explored before.”

Parkinson’s disease is the second-most common neurological disorder after Alzheimer’s, affecting over 100,000 Canadians. It particularly impacts older men, progressively impairing movement and causing pain as well as sleep and mental health issues.

Most previous research efforts to activate the Wnt signaling pathway relied on a GSK3 enzyme inhibitor. This method involves multiple signaling pathways for stem cell proliferation and differentiation, which can have an unintended effect on the newly produced neurons and activate off-target cells.

“We developed an efficient method for stimulating stem cell differentiation to produce neural cells in the midbrain,” said Andy Yang, first author on the study and a PhD student at the Donnelly Centre. “Moreover, cells activated via the FZD5 receptor closely resemble dopaminergic neurons of natural origin.”

Another promising finding of the study, published recently in the journal Development, is that implanting the artificially-produced neurons in a rodent model with Parkinson’s disease led to improvement of the rodent’s locomotive impairment.

“Our next step would be to continue using rodent or other suitable models to compare the outcomes of activating the FZD5 receptor and inhibiting GSK3,” said Yang. “These experiments will confirm which method is more effective in improving symptoms of Parkinson’s disease ahead of clinical trials.”

The research was supported by U of T’s Medicine by Design program, an institutional strategic initiative that receives funding from the Canada First Research Excellence Fund and the Canadian Institutes of Health Research.

U of T, hospitals launch pilot program to boost commercialization of medical innovations

rahul.kalvapalle — Wed, 24 Apr 2024 14:19:19 +0000

U of T, hospitals launch pilot program to boost commercialization of medical innovations

rahul.kalvapalle Wed, 04/24/2024 - 10:19

Cutline

(photo by Daria Perevezentsev)

Rahul Kalvapalle

Topic

Our Community

Acceleration Consortium

Institutional Strategic Initiatives

Sunnybrook Health Sciences Centre

Artificial Intelligence

Department of Chemistry

Department of Computer Science

Entrepreneurship

Faculty of Art & Science

Hospital for Sick Children

Leslie Dan Faculty of Pharmacy

Research & Innovation

Startups

University Health Network

The ��߲ݴ�ý is collaborating with the University Health Network, the Hospital for Sick Children and Sunnybrook Research Institute on a new program that aims to leverage the expertise of entrepreneurs and business leaders to advance commercialization of emerging medical technologies and regenerative medicine research.

Funded by the Government of Ontario, the Entrepreneur-In-Residence program will support projects that display high potential for clinical impact and spin-off company formation, spanning areas ranging from regenerative therapies and medical devices to AI-powered clinical tools and apps for patient care.

The one-year pilot program is being launched with the help of a $300,000 grant from Intellectual Property Ontario (IPON), a provincial agency that was established in 2022 to provide IP resources and supports to researchers and businesses.

“The Entrepreneur-in-Residence program will help take medical innovations developed in academic and hospital environments and translate them into the commercial arena, generating economic opportunity for the region and expanding clinical impact globally,” said Leah Cowen, U of T’s vice-president, research and innovation, and strategic initiatives.

“The ��߲ݴ�ý is grateful to IPON for its support of this initiative, which stands to strengthen existing networks of knowledge exchange and collaboration between the university and its partner hospitals.”

Jill Dunlop, left,Ontario’s minister of colleges and universities, said post-secondary institutions are critical incubators of innovation and commercialization (photo courtesy of IPON)

The program will see Entrepreneurs-in-Residence – individuals with a track record of launching science-based ventures and shepherding projects from proof-of-concept to incubation, acceleration and seed funding – liaise with U of T’s Innovations & Partnerships Office and IPON to generate and protect IP. It is designed to add capacity and scope to U of T’s thriving entrepreneurship and commercialization ecosystem, including existing Entrepreneur-in-Residence initiatives such as those offered by the Temerty Faculty of Medicine and Medicine By Design, an institutional strategic initiative (ISI).

“In today’s global knowledge-based economy, Ontario’s post-secondary institutions are critical – not just as centres of learning, but as incubators for innovation and commercialization,” said Jill Dunlop, minister of colleges and universities, in a recent announcement of new IPON-funded initiatives.

“Through the province’s support of IPON, our government is ensuring the social and economic benefits of publicly funded research stay in our province, so that Ontarians and the Ontario economy benefit from these new discoveries and innovations.”

Dunlop also spoke at an April 8 event with Christine Allen, a professor in U of T’s Leslie Dan Faculty of Pharmacy who has an extensive track record of translating and commercializing lab discoveries.

Christine Allen, far right, is a professor in the Leslie Dan Faculty of Pharmacy and the founder and CEO of Intrepid Labs (photo courtesy of IPON)

At the event, Allen highlighted the growth of her startup, Intrepid Labs Inc., which she co-founded with Alán Aspuru-Guzik, a professor in the departments of chemistry and computer science in U of T’s Faculty of Arts & Science and director of the Acceleration Consortium. The company marries Allen’s prowess in drug formulation and development with Aspuru-Guzik’s expertise in AI and advanced computing in order to accelerate the development of next-generation medicines. In the fall, the company closed a pre-seed round of US$4 million.

“The availability of top-notch talent in AI and life sciences made Toronto a great place to launch our company,” says Allen, who is Intrepid’s CEO, noting all four of the startup’s co-founders are from U of T.

She added that U of T is a powerhouse for entrepreneurship and intellectual property, ranked second in North America for university-based startups, and that companies with founders or co-founders from U of T make up a significant percentage of some of the fastest-growing companies in Ontario.

“This is the beauty of being at the ��߲ݴ�ý and having the MaRS Discovery District across the street and all the hospitals around us. It’s such a rich environment,” she says.

“We can do this in Toronto.”

Allen stressed that a thriving lab-to-market ecosystem is critical to inspire the next generation of entrepreneurs.

“Students are increasingly seeking out roles in the private sector,” she says. “For them to see other students and faculty members [found startups] helps them realize that it’s possible for them to start companies, too.”

What Now? AI, Episode 3: Innovation for Good

Christopher.Sorensen — Thu, 18 Apr 2024 20:47:11 +0000

What Now? AI, Episode 3: Innovation for Good Christopher.Sorensen Thu, 04/18/2024 - 16:47

Topic

Our Community

Temerty Faculty of Medicine

Unity Health

What Now? AI

Schwartz Reisman Institute for Technology and Society

Artificial Intelligence

Computer Science

Faculty of Arts & Science

Faculty of Information

Leslie Dan Faculty of Pharmacy

Research & Innovation

Startups

U of T Mississauga

While the news headlines about AI often focus on dangers and risks, the potential for life-saving innovation in fields such as health care is huge.

In the third episode of What Now? AI, co-hosts Beth Coleman and Rahul Krishnan of the ��߲ݴ�ý are joined by experts Christine Allen and Andrew Pinto to discuss AI’s potential to advance drug development and dramatically improve primary care.

Listen to episode three on Apple, Spotify, SoundCloud, iHeartRadio and Amazon. Watch episode three on YouTube.

Allen, a professor in U of T’s Leslie Dan Faculty of Pharmacy and an expert in drug formulation and development, co-founded Intrepid Labs Inc. with Alán Aspuru-Guzik, a professor in the departments of chemistry and computer science in U of T’s Faculty of Arts & Science.

One of the first startups to emerge from the Acceleration Consortium at U of T, Intrepid Labs is accelerating pharmaceutical drug development through the integration of AI, automation and advanced computing.

“It’s this concept of using AI to explore the unexplored,” Allen says.

“What if that formulation could really transform the properties and performance of your drug is one of those unexplored formulations. That will then take that drug through clinical development smoothly and get it to patients faster, which is really the goal.”

Meanwhile, Pinto, a family physician at St. Michael’s Hospital and director of the Upstream Lab, Unity Health Toronto, focuses his research on addressing the social determinants of health by running clinical trials of interventions and using AI tools for surveillance of respiratory illness.

“When we started to do this work around AI in primary care, we wanted to be directed by primary care providers and patients,” says Pinto, an associate professor in the department of family and community medicine in U of T’s Temerty Faculty of Medicine and at the Dalla Lana School of Public Health.

Reducing health-care inequities is top of mind for Pinto. His lab focuses on implementing AI to prioritize community engagement and bridge socioeconomic gaps to mitigate biases.

“We’re using these tools to look at all of the patients in a population and then focus our attention on the people who need it most.”

About the hosts:

Beth Coleman is an associate professor at U of T Mississauga’s Institute of Communication, Culture, Information and Technology and the Faculty of Information. She is also a research lead on AI policy and praxis at the Schwartz Reisman Institute for Technology and Society. Coleman authored Reality Was Whatever Happened: Octavia Butler AI and Other Possible Worlds using art and generative AI.

Rahul Krishnan is an assistant professor in U of T’s department of computer science in the Faculty of Arts & Science and department of laboratory medicine and pathobiology in the Temerty Faculty of Medicine. He is a Canada CIFAR Chair at the Vector Institute, a faculty affiliate at the Schwartz Reisman Institute for Technology and Society and a faculty member at the Temerty Centre for AI Research and Education in Medicine (T-CAIREM).

Heart-on-a-chip model used to glean insights into COVID-19-induced heart inflammation

Christopher.Sorensen — Mon, 08 Apr 2024 19:06:23 +0000

Heart-on-a-chip model used to glean insights into COVID-19-induced heart inflammation

Christopher.Sorensen Mon, 04/08/2024 - 15:06

Cutline

Researchers worked in the Toronto High Containment Facility at U of T to examine the effects of COVID-19 on heart inflammation (photo by Lisa Lightbourn)

Betty Zou

Topic

Breaking Research

Institute of Biomedical Engineering

Temerty Faculty of Medicine

Unity Health

Alumni

Faculty of Applied Science & Engineering

Leslie Dan Faculty of Pharmacy

Research & Innovation

University Health Network

Subheadline

Researcher dedicates study to her late grandmother, who died from COVID-19-induced heart failure

Researchers at the ��߲ݴ�ý and its partner hospitals have created a unique heart-on-a-chip model that is helping untangle the causes of COVID-19-induced heart inflammation and uncover strategies to reduce its impact.

While COVID-19 is primarily a respiratory infection, clinicians and researchers are increasingly aware of the virus’s effects on other organs – including the heart. Data from the U.S. Centers for Disease Control and Prevention shows patients hospitalized with COVID-19 between March 2020 and January 2021 had 15 times higher risk for developing myocarditis, or inflammation of the heart muscle, compared to patients without COVID-19.

But the biology behind the association between SARS-CoV-2 infection and heart inflammation had remained unclear – in part because there have not been good models with which to study infection-related heart inflammation.

“Conventionally, people grow heart cells in a 2D setting and then expose it to SARS-CoV-2 to see how the virus damages the heart. But that’s not actually what happens in our body,” says Rick Lu, a PhD graduate from U of T’s Institute for Biomedical Engineering who is currently a postdoctoral researcher at U of T’s Leslie Dan Faculty of Pharmacy.

Lu is the first author of a new study published in Science Advances that describes a miniature 3D heart-on-a-chip model that more accurately captures the impact of SARS-CoV-2 infection and its associated immune response on cardiac dysfunction.

The first-of-its-kind model builds on previous work led by Milica Radisic, Lu’s PhD adviser, a senior scientist at University Health Network and a U of T professor of biomedical engineering. The approach uses a lab-made network of blood vessels surrounded by heart tissues grown from stem cells to mimic a real human heart with its tangle of vessels going in and out.

From left to right: Researchers Milica Radisic, Rick Lu and Claudia dos Santos (supplied images)

To examine the effects of COVID-19 on heart inflammation, Lu and his colleagues first had to adapt their model to work in the Toronto High Containment Facility, a specialized lab that allows researchers to study high-risk pathogens like SARS-CoV-2 in a safe and secure way.

“This work would simply not be possible without the Toronto High Containment Facility,” says Radisic, who holds the Canada Research Chair in Organ-on-a-Chip Engineering.

In the high containment lab, the researchers added live virus and immune cells to the blood vessels and allowed them to flow through their mini hearts-on-a-chip, replicating the immune response that happens after a SARS-CoV-2 infection. They found that the combination of SARS-CoV-2 and immune cells reduced the heart’s ability to contract and pump. To understand why, the researchers turned to mitochondria, the tiny energy storehouses that power the muscle’s beating movements. They showed that SARS-CoV-2 infection led to loss of mitochondria and a release of mitochondrial DNA from the heart cells into the nutrient broth used to grow the organoids.

Working with Claudia dos Santos, a scientist and critical care doctor at Unity Health Toronto, associate professor of medicine and Pitts Research Chair in Acute Care and Emergency Medicine at U of T’s Temerty Faculty of Medicine, the researchers then asked whether the presence of freely circulating mitochondrial DNA is also seen in patients experiencing COVID-19-induced heart complications.

They analyzed blood samples from patients with and without COVID-19 and found nearly two-and-a-half times higher levels of mitochondrial DNA in patients who were COVID-19-positive. Their findings point to mitochondrial DNA levels as a powerful predictor of a person’s risk of experiencing cardiac problems after SARS-CoV-2 infection.

The team also showed that a new type of cell-based therapy called exosomes – little cargo vessels that bubble off cells – could reduce inflammation and mitochondria loss, as well as improve heart function, after SARS-CoV-2 infection, highlighting their potential to repair COVID-19-associated heart damage.

By integrating blood vessels and immune cells, Lu hopes that the innovative heart-on-a-chip model can help researchers and clinicians understand and identify treatment strategies for other infection-related heart conditions.

“The good thing about our system is that it’s readily adaptable to any kind of infectious disease,” says Lu. “The other benefit is that we don’t have to rely as much on animal models. Since we’re already using human-derived cells, the clinical translatability is much higher.”

As a next step, Radisic’s group plans to use the miniature organs to uncover why males are more likely than females to experience COVID-19-associated heart complications and to examine the cardiac issues commonly seen in people with long COVID-19.

Radisic says the motivation for this work was deeply personal. She dedicated the study to her late grandmother who died from COVID-19-induced heart failure after six weeks in the intensive care unit.

“The feeling of helplessness is rather profound when a loved one is dying,” she says. “As scientists, we can take small steps toward new cures so that other people do not meet the same fate. For me, this work meant overcoming the feeling of helplessness.”

The work was supported by investments from the Canada Foundation for Innovation and the creation of the U of T COVID-19 biobank and the Precision Medicine in Critical Care (PREDICT) Biobank at Unity Health Toronto – and by the contributions of patients and families that donated biological samples, making significant advances in research possible.

How will AI change our world? U of T podcast explores technology’s impact on society

Christopher.Sorensen — Thu, 04 Apr 2024 15:17:45 +0000

How will AI change our world? U of T podcast explores technology’s impact on society

Christopher.Sorensen Thu, 04/04/2024 - 11:17

Mariam Matti

Topic

Our Community

Temerty Faculty of Medicine

Unity Health

What Now? AI

Schwartz Reisman Institute for Technology and Society

Alumni

Artificial Intelligence

CIFAR

Computer Science

Dalla Lana School of Public Health

Faculty of Arts & Science

Faculty of Information

Faculty of Law

Geoffrey Hinton

Leslie Dan Faculty of Pharmacy

Startups

U of T Mississauga

Vector Institute

Subheadline

In What Now? AI, hosts Beth Coleman and Rahul Krishnan explore – and demystify – artificial intelligence and its impact on society with the help of leading experts

Rapid advances in artificial intelligence are posing profound questions about the future – and about us.

Can we ensure safety and alignment within AI systems? How might AI forever transform fields like health care? What ripple effects could AI have on jobs and livelihoods, including in creative industries?

��߲ݴ�ý researchers Beth Coleman and Rahul Krishnan explore – and demystify – these and other topics by tapping into the knowledge of leading AI experts in What Now? AI, a new U of T podcast that launches this week.

It can be found on Apple, Spotify, Soundcloud, iHeartRadio and Amazon.

An associate professor at U of T Mississauga’s Institute of Communication, Culture, Information and Technology and the Faculty of Information, Coleman says she hopes the episodes help audiences make sense of new AI tools and systems by cutting through “all the noisiness and controversy that has taken over the headlines.”

“It can be complex and technical, but it’s also social,” says Coleman, a research lead on AI policy and praxis at the Schwartz Reisman Institute for Technology & Society.

“What we do with AI makes a difference and more people need to be able to share that knowledge.”

Coleman’s own research centres around technology and society with a focus on data and cities, AI and policy, and generative arts. Inspired by Octavia Butler’s 1980 Xenogenesis trilogy, Coleman authored Reality Was Whatever Happened: Octavia Butler AI and Other Possible Worlds using art and generative AI.

Krishnan, meanwhile, is an assistant professor in U of T’s department of computer science in the Faculty of Arts & Science and department of laboratory medicine and pathobiology in the Temerty Faculty of Medicine. A Canada CIFAR AI Chair at the Vector Institute and Canada Research Chair in computational medicine, Krishnan and his team focus on teaching neural networks about causality, building deep learning models that analyze cause and effect from data.

“I’m excited to co-host this podcast to explore and demystify for a broader audience AI through the lens of an accomplished and diverse set of experts,” says Krishnan, who is also a faculty affiliate at the Schwartz Reisman Institute for Technology and Society and a faculty member at the Temerty Centre for AI Research and Education in Medicine (T-CAIREM).

What Now? AI picks up where the conversation started last year by Geoffrey Hinton, the cognitive psychologist and University Professor emeritus of computer science who is known as the “Godfather of AI.” After a lifetime spent developing a type of AI known as deep learning, Hinton stepped back from his role at Google to warn about the existential threats of unchecked AI development.

Since then, there have been ongoing advancements in AI research, technological applications and policy development.

Coleman and Krishnan will tackle these and other topics with guests:

Gillian Hadfield, professor of law and strategic management at the Faculty of Law and the Schwartz Reisman Chair in Technology and Society.
Roger Grosse, associate professor of computer science in the Faculty of Arts & Science and founding member of the Vector Institute.
Christine Allen, professor at the Leslie Dan Faculty of Pharmacy and co-founder and CEO of Intrepid Labs Inc.
Andrew Pinto, a family physician at St. Michael’s Hospital, Unity Health Toronto, and associate professor in the Temerty Faculty of Medicine and the Dalla Lana School of Public Health.
Nick Frosst, co-founder of Cohere, singer in Good Kid band and a U of T computer science and cognitive science alumnus.

“The What Now? AI podcast highlights the incredible researchers at the ��߲ݴ�ý who are exploring the profound implications of this transformative technology,” says Leah Cowen, U of T’s vice-president, research and innovation, and strategic initiatives. “These discussions tackle critical questions surrounding AI safety and alignment and its myriad implications across various domains.

“The university is committed to fostering informed discussions that will shape our collective understanding of AI’s role in our society and in our future.”

Coleman says she hopes listeners come away from the podcast feeling more grounded.

Krishnan, for his part, wants the audience to understand “that there is no one group that has ownership” over the technology” and that “the free exchange of ideas and open-source tools encourage people from all disciplines to come see how accessible AI can be, what AI can do for them and how they can advance the discourse in the field.”

Leslie Dan Faculty of Pharmacy

PhD student's radiopharmaceutical to play key role in clinical trial for lung cancer treatment

Why it's important to get your 2024 flu shot – and how to get it

What is influenza?

When to get the influenza vaccine

Where to get the influenza vaccine

Learn more about vaccines at ���߲ݴ�ý

U of T receives $25-million gift from Myron and Berna Garron for Scarborough Academy of Medicine and Integrated Health

Helping to revitalize the health-care landscape

A community of support

U of T leaders react

U of T community members recognized with Order of Canada

Current and former faculty

Alumni and friends

‘Give yourself grace’: Pharmacy grad from Nigeria reflects on U of T journey

U of T researchers' approach to producing neural cells could yield new treatments for Parkinson’s

U of T, hospitals launch pilot program to boost commercialization of medical innovations

What Now? AI, Episode 3: Innovation for Good

About the hosts:

Heart-on-a-chip model used to glean insights into COVID-19-induced heart inflammation

How will AI change our world? U of T podcast explores technology’s impact on society

Learn more about vaccines at ��߲ݴ�ý